Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

Welcome to the Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

The brain is a highly complex organ and ubiquitous in our daily lives. However, little is understood about it or its functions. Undertaking the study of this organ is a challenging and fascinating endeavour and can spawn new technologies and alternative methods of treatment of diseases. Research at the Institute of Computational and Systems Neuroscience encompasses theoretical, data-analytic and simulation approaches to develop multi-scale models of the brain. It is our firm belief that progress in understanding a complex system like the brain can only be achieved through this multi-faceted approach.

Directors: Prof. Dr. Sonja Grün and Prof. Dr. Markus Diesmann

Institute for Advanced Simulation (IAS-6), Computational and Systems Neuroscience

Computational Neurophysics group

The focus of the group of Markus Diesmann are bottom-up approaches in order to integrate physiological and anatomical data into models, in particular model development, theory of neuronal networks, and correlation dynamics. This also requires the development of simulation technology for neural networks.

Lead: Markus Diesmann, Director of IAS-6/ INM-10

Statistical Neuroscience

The research group of Sonja Grün (IAS-6) focuses on the development of analysis strategies and tools that uncover concerted activity in electrophysiological signals from the brain.

Lead: Sonja Grün, Director of IAS-6/ INM-10

Computation in Neural Circuits

Investigation of mechanisms underlying neural computation through the development of models on the level of networks of spiking neurons. The group of Abigail Morrison (IAS-6) applies a predominantly top-down approach to discover functional constraints on structure, plasticity and dynamics, particularly with respect to learning and memory.

Lead: Abigail Morrison

Theory of Multi-scale Neuronal Networks

The focus of this group are mechanisms that shape the dynamics and information processing in biological and artificial neuronal networks. On the side of biological networks, we are interested in the relationship between the structure and dynamics of neural networks to unveil experimentally testable mechanisms of collective phenomena. For artificial neuronal networks, we develop the physics of AI that allows us to understand and quantify generalization properties and learning. Employing and developing statistical physics methods to formulate biological and artificial networks in a unified language, allows us to discover overarching principles of information processing and to detect and quantify qualitative differences.

Lead: Moritz Helias

Theoretical Neuroanatomy

The work group led by Sacha van Albada (IAS-6) studies the architecture and connectivity of brain circuits as the basis for neural network models at the resolution of neurons and synapses that relate structure to dynamics.

Lead: Sacha van Albada

Team Data Science of Electro- and Optophysiology in Behavioural Neuroscience

The team of Michael Denker (IAS-6) addresses the practical challenges that arise in the context of data management and reproducible data analytics in neuroscience by applying concepts from physics and computer science.

Lead: Michael Denker

Team Future Simulation Architectures

Embracing the evolving landscape of high-performance computing systems, the team of Johanna Senk identifies challenges and explores solutions for neural network simulation technology.

Lead: Johanna Senk

News and Events

NEST Conference 2024

On 17th and 18th June, the NEST Conference 2024 brought together over 50 participants from around the world to discuss the latest developments and applications in neural simulation technology in general and NEST simulation code in particular.

ANDA-NI

Apply now for the Advanced Neural Data Analysis and Neuroinformatics School (ANDA-NI), a successor of the popular ANDA courses held since 2017. The school is comprised of a series of online preparatory lectures in September 2024, an extended time period of instructed data curation and a one-week hands-on, in-person workshop in November 2024 at the Research Center Jülich, Germany.

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Latest Publications

Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region

Morales-Gregorio A., Kurth AC., Ito J., Kleinjohann A., Barthélemy FV., Brochier T., Grün S., van Albada SJ.

Cell Reports 43(7): 114371

10.1016/j.celrep.2024.114371

Software in science is ubiquitous yet overlooked

Facilitating the Sharing of Electrophysiology Data Analysis Results Through In-Depth Provenance Capture

A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets

Neuronal Population Activity in Macaque Visual Cortices Dynamically Changes through Repeated Fixations in Active Free Viewing

Sequence learning in a spiking neuronal network with memristive synapses Neuromorphic Computing and Engineering

Runtime Construction of Large-Scale Spiking Neuronal Network Models on GPU Devices