Amyloid Fibril Structures
Amyloids are highly ordered protein aggregates implicated in various neurodegenerative diseases, including Alzheimer’s (AD) and Parkinson’s (AD) diseases, as well as metabolic disorders like Type 2 Diabetes.
Molecular Structure and Biophysics
Determination of amyloid fibril structures by cryo-EM
About
The Schröder group studies the molecular basis of amyloid-related diseases, including Alzheimer's, Parkinsons's, and diabetes. Using cryo-electron microscopy (cryo-EM), we determine the structures of amyloid proteins to gain insights into their aggregation and pathological roles. Furthermore, the group develops computational methods for modeling and refinement of protein structures from low-resolution data and explores applications in protein and peptide design.
Research Topics
Amyloid fibril structures, Cryo-EM, protein design and structure prediction, computational method development
Group Members
Selected Publications
Last Modified: 24.03.2025