Bioelektronik (IBI-3)

With the ultimate goal to treat neurodegenerative diseases, restore lost neuronal functions, and understand the complex neural networks within the central and peripheral nervous system, we are developing neural interfaces for in vivo applications. Up to date, one of the main challenges in neural technology is the immune response that leads to implant rejection when using stiff implants, such as silicon-based probes, or implants with a big insertion footprint. The latter affects the stability of the devices when implanted for long periods (months).

In the In vivo Neuroelectronics group, we develop bidirectional stealth neurotechnology for seamless integration with the body, allowing in turn, monitoring and modulating neuronal activity via electrical, optical, or chemical methods. Thus, we try to overcome the current shortcomings of neural implants from different angles. First, we customize our designs and technology for application-specific implantable neuroelectronic interfaces. Here, we investigate and work with new designs and materials to match the mechanical, dimensional, electrochemical, and biological requirements of our target applications. The latter, comprises the use of polymeric materials and MEMS-based technology, procuring also different electrode coatings to achieve proper electrochemical capabilities in our probes. Additionally, we investigate implantation methods to minimize insertion footprint and trauma. Furthermore, we characterize and test our devices with in vitro, ex vivo, and cadaveric animal models, allowing us to predict their performance and test them in the intended in vivo application for acute and chronic settings. Currently, we are working on the development of different neural applications, from the brain and peripheral nerve implants to miniaturized visual prostheses.