Novel CDTA-based, Bifunctional Chelators for Stable and Inert Mn^II Complexation

The synthesis of two CDTA-based bifunctional Mn^II chelators (BFMnCs) reactive in “click” chemistry is reported. A “click” conjugate of one BFMnC was used to perform a detailed thermodynamic, kinetic, and relaxometric assessment of the corresponding Mn^II complex. As demonstrated by the exquisite balance between thermodynamic stability, kinetic inertness, and relaxivity of the chelate, the reported BFMnCs are promising precursors for Mn^II-based PET/MR tracers (^52g/55Mn^II) as well as MR contrast agents (Mn^II) of the next generation.

C. Vanasschen, E. Molnár, G. Tircsó, F.K. Kálmán, É. Tóth, M. Brandt, H.H. Coenen, B. Neumaier, Novel CDTA-based, Bifunctional Chelators for Stable and Inert MnII Complexation: Synthesis and Physicochemical

Characterization, Inorg. Chem. 56, 7746(2017); [doi:10.1021/acs.inorgchem.7b00460].