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Development and application of ultra-high resolution relaxation time and water content mapping

Quantitative MRI (qMRI) imaging has gained a lot attention due to its ability to provide very specific and reproducible information. Analysing water content in the brain in vivo is an interesting and challenging application of qMRI. The tissue water content - or MR-visible proton density (PD) - as obtained using qMRI, is a very precise indicator of tissue hydration state. This technique is therefore thought to be useful for the study of many cerebral diseases, including, cerebral oedema, brain tumour and multiple sclerosis. Partial volume effect, caused by the limited resolution of the acquired MR images and the rather long examination time required for a quantitative water content protocol are two important limitations. This project aims to explore new possibilities so as to improve the efficiency of the quantitative MRI protocol which will allow pushing back these limits:

  • qMRI at ultra-high field strength
  • qMRI with ultra-short TR sequences
  • Motion corrected MRI acquisition

Development and application of ultra-high resolution relaxation time and water content mapping


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