Structural and functional organisation of the brain

INM-1 will develop a 3D model of the human brain, taking into account cytoarchitectonics, connectivity, molecular structure, genetics and brain function.

Profil

Julich-Brain

The Julich-Brain Atlas

"Julich-Brain" is the name of the first 3D atlas of the human brain, which depicts the variability of the brain structure with microscopic resolution. Over 24,000 wafer-thin brain slices were digitised, assembled in 3D and mapped by experts.

Big Brain HIBALL

Helmholtz International BigBrain Analytics and Learning Laboratory

HIBALL builds on INM-1's collaboration with McGill University around the 20-micron BigBrain model and will enable the development of a 3-D atlas of the human brain at cellular resolution level.

BigBrain EBRAINS

Brain Atlas of the Human Brain Project

The INM-1 creates a digital brain atlas in 3D, which links the collected knowledge of brain research spatially precise. The atlas is a contribution to the European flagship "Human Brain Project" and part of the new EU research platform EBRAINS.

Computing Brain

Computing Brain

The INM-1 builds 3D models of the human brain at the level of individual cells and nerve fibers by processing Terabytes of image data. This is only possible by developing complex distributed workflows on the Supercomputing systems in Jülich.

Areas of Research

Architecture and Brain Function

Architecture and Brain Function

Architektonik und Hirnfunktion

The goal of the research group "Architecture and Brain Function" is to gain a new understanding of the organisational principles of the human brain and to better understand how brain structure is related to function and behavior.

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Big Data Analytics

Big Data Analytics

Bild der Arbeitsgruppe "Big Data Analytics"

The Big Data Analytics group develops software and methodology to build a microscopic resolution 3D model of the human brain, which includes detailed information about the spatial arrangement and the properties of neuronal cells and nerve fibers, and highly precise 3D maps of brain areas.

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Clinical Neuroanatomy

Clinical Neuroanatomy

Eine Darstellung der Krankheitsbilder

The aim of the research group "Clinical Neuroanatomy" is on the one hand to understand the neuroanatomical causes of various movement disorders in vivo and post mortem in order to enable an early diagnosis and identify biomarkers for possible therapies and on the other hand to distinguish primarily age-related changes in motor function from pathological movement disorders.

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Connectivity

Connectivity

Bild Konnektivität

The „Connectivity“ group is interested in the relevance of fiber tracts for the structure and architecture of the surface and cortex of the brain. A particular focus are changes in the anatomy of the brain’s surface and fiber tracts at older age.

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Fiber Architecture

Fiber Architecture

Faserbahnarchitektur

The research group “Fiber Architecture (FA)” develops the 3D Polarized Light Imaging (3D-PLI) technology to reveal the structural connectivity and fiber architecture in post mortem brains at microscopic resolution.

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Genomic Imaging

Genomic Imaging

Schematic representation of basic „genomic imaging“ research strategies

The research group „Genomic Imaging“ studies the influence of genetic factors on structure and function of the human brain.

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Neuroanatomy of Language

Neuroanatomy of Language

Sprechen als komplexe Gehirnleistung

Language is a complex cognitive ability unique for humans. The working group “Neuroanatomy of Language” conducts systematic analyses of the relationship of brain structure and function.

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Receptors

Receptors

Neurotransmitter receptor

Neurotransmitters and their receptors represent the molecular basis for structure-function relationships in the brain. Each brain area contains nerve cells that express receptors for inhibitory, excitatory and modulatory neurotransmitters. Differences in the regional and laminar distribution patterns of a single receptor type can be analysed by quantitative in vitro receptor autoradiography.

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Laboratory

Laboratory

Einblick ins Labor

The lab team deals with the processing of brain tissue. This includes tissue preparation, fixation, embedding, cutting, staining and first steps of evaluation.

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