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Advertising division: ER-C-3 - Structural Biology
Reference number: Biochemistry/cell biology, biophysics

PhD position: Multiscale imaging approach of ESCRT-III membrane remodeling events

Advertising institutes:
Heinrich-Heine University, Institute of Genetics & Forschungszentrum Jülich/ERC-3 – Structural Biology

PIs: Prof. Thomas Klein and Prof. Carsten Sachse

A PhD position is available for a joint project between Heinrich-Heine-University and Forschungszentrum Jülich: Our aim is to elucidate the structure of ESCRT-III complexes with lipid membranes by a combination of in vitro structural cryo-EM and light microscopic functional analysis in Drosophila.

The research will be carried out in collaboration at both institutions the Heinrich-Heine University and the Forschungszentrum Jülich. The Heinrich Heine University Düsseldorf is one of the younger higher education institutions in the state of North Rhine-Westphalia. Today around 25,000 students study at a modern compact campus under conditions ideally suited to academic life. The Forschungzentrum Jülich is one of the largest research centers in Germany, with excellent scientific equipment including state-of-the-art cryo-microscopes and leading European computational resources, located on a green campus, and near the cultural centers Köln, Düsseldorf, and Aachen. The project will be embedded in the iGRADbio Graduate Program (https://www.biologie.hhu.de/startseite-biologie/igradbio-graduate-program.html)

The successful candidate should have a master degree in biochemistry/cell biology, biophysics or related field. The candidate will be working on high-resolution cryo-EM structure determination of purified endosomal sorting complexes required for transport (ESCRT) proteins and/or in situ imaging of cellular samples using correlative light and electron microscopy approaches. The goal of the Institute of Genetics and ERC-3 institute is to shed light on the structural principles of the essential cellular membrane trafficking mechanisms mediated by ESCRTs.

The candidate will be working in a creative and international environment embedded in an interdisciplinary team with colleagues ranging from electron microscopists, computer scientists, biochemists as well as cellular biologists. The 3-year PhD position is immediately available. Payment of the PhD fellow will be based on salary grade EG 13 (50%) Collective Agreement for the Civil Service (TVöD).

Contact:
Complete applications should include a CV and the name and emails of two references, along with a motivation letter, and have to be submitted to Prof. Dr. Thomas Klein (thomas.klein@hhu.de) and Prof. Dr. Carsten Sachse (c.sachse@fz-juelich.de). More detailed information on the scientific interests of the Klein group and Sachse group can be found on https://www.genetics.hhu.de/ and http://sachse.fz-juelich.de / http://www.fz-juelich.de/er-c/er-c-3.

The received documents will be screened by an evaluating committee and, based on the expertise and the records of the scientific career; the shortlisted candidates will be invited for an interview, by teleconference if necessary.

This advertisement as pdf file:  PhD position: Multiscale imaging approach of ESCRT-III membrane remodeling events (PDF, 307 kB)