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Physics of Living Matter Seminar:
Physics of early embryo morphogenesis

Herve Turlier

Multiscale Physics of Morphogenesis, Center for Interdisciplinary Research in Biology, CNRS and College de France


Anfang
18.02.2021 11:00 Uhr
Veranstaltungsort
Remote access

Join us at: www.fz-juelich.de/ibi/TPLMSem

Abstract:

Early embryogenesis is archetypal of a self-organized process, where the emergence of a complex structure stems from the interaction of its elementary parts. Progress in imaging and molecular genetics allow us to delve into embryos at unprecedented spatiotemporal resolutions, but extracting biophysical information from such complex multidimensional data is a highly technical challenge. In this talk I will present some of our recent efforts to develop physical models and novel analysis methods of early embryo development.

Theoretical Physics Copyright: Herve Turlier

I will the physical requirements for the emergence and positioning of a cavity in early mammalian embryos and discuss novel approaches to segment cell interfaces and to infer cell mechanical properties from confocal microscopy images of cell membranes. I will conclude on perspectives at the frontier of machine learning and physical modeling to reverse-engineer the sequence of biochemical and mechanical events that build an early embryo.

Kontakt

Dr. Dmitry Fedosov
Telefon: +49 2461 61-2972
Fax: +49 2461 61-3180
E-Mail: d.fedosov@fz-juelich.de