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Parkinson’s Disease: Insights into the Formation of Harmful Protein Deposits

Jülich researchers observe breaks in the growth of protein fibrils

Jülich, 9 March 2015 – One of the characteristics of Parkinson’s disease is that tiny threads of endogenous protein form deposits in the brain. Using a special microscopy method, researchers from Jülich and Düsseldorf were able to make direct and time-resolved observations of the formation of these alpha-synuclein fibrils for the first time. They found that fibril growth follows a "stop and go" pattern. Their findings have been published in the current issue of the Journal of Molecular Biology.

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