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Institute of Neuroscience and Medicine

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Bild von David Gräßel

Dipl.-Phys. David Gräßel

Research fellow

Degree: Master of Science, RWTH Aachen

Research Topics:

Polarized Light Imaging (3D-PLI) - High resolution imaging of nerve fiber tracts in the brain using polarized light.
The Connectome project dedicated to reveal the connectivity of interacting brain regions involves different neuroimaging techniques such as optical microscopy and diffusion weighted magnetic resonance imaging. Three-dimensional Polarized Light Imaging (3D PLI) is an innovative approach to map the spatial orientations of nerve fibers in unstained histological sections of the brain at the micrometer scale. The principle of 3D-PLI is based on the birefringent properties of the myelin sheaths surrounding nerve axons.
Research Methods:Forschungsschwerpunkt:

Research Methods:

  • 3D-Vectormapping of the fiber architecture (60 down to 1,6 microns)
  • 3D-Animation and visualization of neuronal fiber models with Matlab®
  • Fully automatized hardware programming with LabView®
  • Theory of polarized light propagation in uniaxial birefringent tissue


Institute of Neuroscience and Medicine (INM-1)
Forschungszentrum Jülich
52425 Jülich


Phone: +49 2461 61-4774
Fax: +49 2461 61-3483